GlaxoSmithKline

Antimalarial Drug Discovery. Plasmodium Biology. Antimalarial Resistance and MoA

Laboratory Contributions

• In vitro culture of asexual and sexual Plasmodium parasites
• Monitoring efficacy of antimalaril compounds
• Assessment and isolation of both in vitro and in vivo resistance
• Determination of in vitro Killing Rates (PRR)
• In vivo humanized mouse model
• In vivo P. berghei liver model
• In silico profiling of antimalarials